Full text data of ZNF180
ZNF180
[Confidence: low (only semi-automatic identification from reviews)]
Zinc finger protein 180 (HHZ168)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Zinc finger protein 180 (HHZ168)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9UJW8
ID ZN180_HUMAN Reviewed; 692 AA.
AC Q9UJW8; B2RCN6; Q9P1U2;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 06-MAR-2007, sequence version 2.
DT 22-JAN-2014, entry version 112.
DE RecName: Full=Zinc finger protein 180;
DE AltName: Full=HHZ168;
GN Name=ZNF180;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-41 AND CYS-89 AND
RP SER-272.
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC -!- SIMILARITY: Contains 1 KRAB domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF192913; AAF07950.1; -; mRNA.
DR EMBL; AK315193; BAG37633.1; -; mRNA.
DR EMBL; AC069278; AAF71790.1; -; Genomic_DNA.
DR EMBL; CH471126; EAW57279.1; -; Genomic_DNA.
DR RefSeq; NP_001265437.1; NM_001278508.1.
DR RefSeq; NP_001265438.1; NM_001278509.1.
DR RefSeq; NP_037388.2; NM_013256.4.
DR UniGene; Hs.22305; -.
DR UniGene; Hs.720205; -.
DR ProteinModelPortal; Q9UJW8; -.
DR SMR; Q9UJW8; 256-684.
DR PhosphoSite; Q9UJW8; -.
DR DMDM; 134044257; -.
DR PaxDb; Q9UJW8; -.
DR PRIDE; Q9UJW8; -.
DR DNASU; 7733; -.
DR Ensembl; ENST00000221327; ENSP00000221327; ENSG00000167384.
DR GeneID; 7733; -.
DR KEGG; hsa:7733; -.
DR UCSC; uc002ozf.4; human.
DR CTD; 7733; -.
DR GeneCards; GC19M044979; -.
DR HGNC; HGNC:12970; ZNF180.
DR HPA; HPA028979; -.
DR HPA; HPA028980; -.
DR MIM; 606740; gene.
DR neXtProt; NX_Q9UJW8; -.
DR PharmGKB; PA37552; -.
DR eggNOG; COG5048; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q9UJW8; -.
DR KO; K09228; -.
DR OMA; EVAFTQR; -.
DR PhylomeDB; Q9UJW8; -.
DR Reactome; REACT_71; Gene Expression.
DR GenomeRNAi; 7733; -.
DR NextBio; 29944; -.
DR PRO; PR:Q9UJW8; -.
DR ArrayExpress; Q9UJW8; -.
DR Bgee; Q9UJW8; -.
DR CleanEx; HS_ZNF180; -.
DR Genevestigator; Q9UJW8; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 12.
DR InterPro; IPR001909; Krueppel-associated_box.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 692 Zinc finger protein 180.
FT /FTId=PRO_0000047442.
FT DOMAIN 72 145 KRAB.
FT ZN_FING 353 375 C2H2-type 1.
FT ZN_FING 381 403 C2H2-type 2.
FT ZN_FING 409 431 C2H2-type 3.
FT ZN_FING 437 459 C2H2-type 4.
FT ZN_FING 465 487 C2H2-type 5.
FT ZN_FING 493 515 C2H2-type 6.
FT ZN_FING 521 543 C2H2-type 7.
FT ZN_FING 549 571 C2H2-type 8.
FT ZN_FING 577 599 C2H2-type 9.
FT ZN_FING 605 627 C2H2-type 10.
FT ZN_FING 633 655 C2H2-type 11.
FT ZN_FING 661 683 C2H2-type 12.
FT VARIANT 41 41 A -> V (in dbSNP:rs2571108).
FT /FTId=VAR_030864.
FT VARIANT 89 89 W -> C (in dbSNP:rs2253563).
FT /FTId=VAR_030865.
FT VARIANT 272 272 C -> S (in dbSNP:rs1897820).
FT /FTId=VAR_030866.
SQ SEQUENCE 692 AA; 79111 MW; 689812AB1E277525 CRC64;
MRACAGSTRE AGSGAQDLST LLCLEESMEE QDEKPPEPPK ACAQDSFLPQ EIIIKVEGED
TGSLTIPSQE GVNFKIVTVD FTREEQGTWN PAQRTLDRDV ILENHRDLVS WDLATAVGKK
DSTSKQRIFD EEPANGVKIE RFTRDDPWLS SCEEVDDCKD QLEKQQEKQE ILLQEVAFTQ
RKAVIHERVC KSDETGEKSG LNSSLFSSPV IPIRNHFHKH VSHAKKWHLN AAVNSHQKIN
ENETLYENNE CGKPPQSIHL IQFTRTQTKD KCYGFSDRIQ SFCHGTPLHI HEKIHGGGKT
FDFKECGQVL NPKISHNEQQ RIPFEESQYK CSETSHSSSL TQNMRNNSEE KPFECNQCGK
SFSWSSHLVA HQRTHTGEKP YECSECGKSF SRSSHLVSHQ RTHTGEKPYR CNQCGKSFSQ
SYVLVVHQRT HTGEKPYECN QCGKSFRQSY KLIAHQRTHT GEKPYECNQC GKSFIQSYKL
IAHQRIHTGE KPYECNQCGK SFSQSYKLVA HQRTHTGEKP FECNQCGKSF SWSSQLVAHQ
RTHTGEKPYE CSECGKSFNR SSHLVMHQRI HTGEKPYECN QCGKSFSQSY VLVVHQRTHT
GEKPYECSQC GKSFRQSSCL TQHQRTHTGE KPFECNQCGK TFSLSARLIV HQRTHTGEKP
FTCIQCGKAF INSYKLIRHQ ATHTEEKLYE CN
//
ID ZN180_HUMAN Reviewed; 692 AA.
AC Q9UJW8; B2RCN6; Q9P1U2;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 06-MAR-2007, sequence version 2.
DT 22-JAN-2014, entry version 112.
DE RecName: Full=Zinc finger protein 180;
DE AltName: Full=HHZ168;
GN Name=ZNF180;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-41 AND CYS-89 AND
RP SER-272.
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC -!- SIMILARITY: Contains 1 KRAB domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF192913; AAF07950.1; -; mRNA.
DR EMBL; AK315193; BAG37633.1; -; mRNA.
DR EMBL; AC069278; AAF71790.1; -; Genomic_DNA.
DR EMBL; CH471126; EAW57279.1; -; Genomic_DNA.
DR RefSeq; NP_001265437.1; NM_001278508.1.
DR RefSeq; NP_001265438.1; NM_001278509.1.
DR RefSeq; NP_037388.2; NM_013256.4.
DR UniGene; Hs.22305; -.
DR UniGene; Hs.720205; -.
DR ProteinModelPortal; Q9UJW8; -.
DR SMR; Q9UJW8; 256-684.
DR PhosphoSite; Q9UJW8; -.
DR DMDM; 134044257; -.
DR PaxDb; Q9UJW8; -.
DR PRIDE; Q9UJW8; -.
DR DNASU; 7733; -.
DR Ensembl; ENST00000221327; ENSP00000221327; ENSG00000167384.
DR GeneID; 7733; -.
DR KEGG; hsa:7733; -.
DR UCSC; uc002ozf.4; human.
DR CTD; 7733; -.
DR GeneCards; GC19M044979; -.
DR HGNC; HGNC:12970; ZNF180.
DR HPA; HPA028979; -.
DR HPA; HPA028980; -.
DR MIM; 606740; gene.
DR neXtProt; NX_Q9UJW8; -.
DR PharmGKB; PA37552; -.
DR eggNOG; COG5048; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q9UJW8; -.
DR KO; K09228; -.
DR OMA; EVAFTQR; -.
DR PhylomeDB; Q9UJW8; -.
DR Reactome; REACT_71; Gene Expression.
DR GenomeRNAi; 7733; -.
DR NextBio; 29944; -.
DR PRO; PR:Q9UJW8; -.
DR ArrayExpress; Q9UJW8; -.
DR Bgee; Q9UJW8; -.
DR CleanEx; HS_ZNF180; -.
DR Genevestigator; Q9UJW8; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 12.
DR InterPro; IPR001909; Krueppel-associated_box.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 692 Zinc finger protein 180.
FT /FTId=PRO_0000047442.
FT DOMAIN 72 145 KRAB.
FT ZN_FING 353 375 C2H2-type 1.
FT ZN_FING 381 403 C2H2-type 2.
FT ZN_FING 409 431 C2H2-type 3.
FT ZN_FING 437 459 C2H2-type 4.
FT ZN_FING 465 487 C2H2-type 5.
FT ZN_FING 493 515 C2H2-type 6.
FT ZN_FING 521 543 C2H2-type 7.
FT ZN_FING 549 571 C2H2-type 8.
FT ZN_FING 577 599 C2H2-type 9.
FT ZN_FING 605 627 C2H2-type 10.
FT ZN_FING 633 655 C2H2-type 11.
FT ZN_FING 661 683 C2H2-type 12.
FT VARIANT 41 41 A -> V (in dbSNP:rs2571108).
FT /FTId=VAR_030864.
FT VARIANT 89 89 W -> C (in dbSNP:rs2253563).
FT /FTId=VAR_030865.
FT VARIANT 272 272 C -> S (in dbSNP:rs1897820).
FT /FTId=VAR_030866.
SQ SEQUENCE 692 AA; 79111 MW; 689812AB1E277525 CRC64;
MRACAGSTRE AGSGAQDLST LLCLEESMEE QDEKPPEPPK ACAQDSFLPQ EIIIKVEGED
TGSLTIPSQE GVNFKIVTVD FTREEQGTWN PAQRTLDRDV ILENHRDLVS WDLATAVGKK
DSTSKQRIFD EEPANGVKIE RFTRDDPWLS SCEEVDDCKD QLEKQQEKQE ILLQEVAFTQ
RKAVIHERVC KSDETGEKSG LNSSLFSSPV IPIRNHFHKH VSHAKKWHLN AAVNSHQKIN
ENETLYENNE CGKPPQSIHL IQFTRTQTKD KCYGFSDRIQ SFCHGTPLHI HEKIHGGGKT
FDFKECGQVL NPKISHNEQQ RIPFEESQYK CSETSHSSSL TQNMRNNSEE KPFECNQCGK
SFSWSSHLVA HQRTHTGEKP YECSECGKSF SRSSHLVSHQ RTHTGEKPYR CNQCGKSFSQ
SYVLVVHQRT HTGEKPYECN QCGKSFRQSY KLIAHQRTHT GEKPYECNQC GKSFIQSYKL
IAHQRIHTGE KPYECNQCGK SFSQSYKLVA HQRTHTGEKP FECNQCGKSF SWSSQLVAHQ
RTHTGEKPYE CSECGKSFNR SSHLVMHQRI HTGEKPYECN QCGKSFSQSY VLVVHQRTHT
GEKPYECSQC GKSFRQSSCL TQHQRTHTGE KPFECNQCGK TFSLSARLIV HQRTHTGEKP
FTCIQCGKAF INSYKLIRHQ ATHTEEKLYE CN
//
MIM
606740
*RECORD*
*FIELD* NO
606740
*FIELD* TI
*606740 ZINC FINGER PROTEIN 180; ZNF180
*FIELD* TX
DESCRIPTION
Zinc finger proteins have been shown to interact with nucleic acids and
read moreto have diverse functions. The zinc finger domain is a conserved amino
acid sequence motif containing 2 specifically positioned cysteines and 2
histidines that are involved in coordinating zinc. Kruppel-related
proteins form 1 family of zinc finger proteins. See 604749 for
additional information on zinc finger proteins.
CLONING
By screening a human fetal heart cDNA library with a degenerate
oligonucleotide based on the consensus sequence of the C2H2 zinc finger
domain, Wang et al. (1996) cloned 2 novel zinc finger cDNAs, designated
ZNF180 and ZNF181 (606741).
MAPPING
By FISH, Wang et al. (1996) mapped the ZNF180 and ZNF181 genes within a
cluster of zinc finger genes on chromosome 19q13.2.
*FIELD* RF
1. Wang, R.; Cukerman, E.; Heng, H. H. Q.; Liew, C.-C.: Identification
of a locus of zinc finger genes in human chromosome 19q13.1-q13.3
region by fluorescence in situ hybridization. Somat. Cell Molec.
Genet. 22: 245-248, 1996.
*FIELD* CD
Carol A. Bocchini: 3/1/2002
*FIELD* ED
terry: 03/01/2002
carol: 3/1/2002
*RECORD*
*FIELD* NO
606740
*FIELD* TI
*606740 ZINC FINGER PROTEIN 180; ZNF180
*FIELD* TX
DESCRIPTION
Zinc finger proteins have been shown to interact with nucleic acids and
read moreto have diverse functions. The zinc finger domain is a conserved amino
acid sequence motif containing 2 specifically positioned cysteines and 2
histidines that are involved in coordinating zinc. Kruppel-related
proteins form 1 family of zinc finger proteins. See 604749 for
additional information on zinc finger proteins.
CLONING
By screening a human fetal heart cDNA library with a degenerate
oligonucleotide based on the consensus sequence of the C2H2 zinc finger
domain, Wang et al. (1996) cloned 2 novel zinc finger cDNAs, designated
ZNF180 and ZNF181 (606741).
MAPPING
By FISH, Wang et al. (1996) mapped the ZNF180 and ZNF181 genes within a
cluster of zinc finger genes on chromosome 19q13.2.
*FIELD* RF
1. Wang, R.; Cukerman, E.; Heng, H. H. Q.; Liew, C.-C.: Identification
of a locus of zinc finger genes in human chromosome 19q13.1-q13.3
region by fluorescence in situ hybridization. Somat. Cell Molec.
Genet. 22: 245-248, 1996.
*FIELD* CD
Carol A. Bocchini: 3/1/2002
*FIELD* ED
terry: 03/01/2002
carol: 3/1/2002