Full text data of ZNF516
ZNF516
(KIAA0222)
[Confidence: low (only semi-automatic identification from reviews)]
Zinc finger protein 516
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Zinc finger protein 516
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q92618
ID ZN516_HUMAN Reviewed; 1163 AA.
AC Q92618;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-FEB-1997, sequence version 1.
DT 22-JAN-2014, entry version 117.
DE RecName: Full=Zinc finger protein 516;
GN Name=ZNF516; Synonyms=KIAA0222;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. VI.
RT The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by
RT analysis of cDNA clones from cell line KG-1 and brain.";
RL DNA Res. 3:321-329(1996).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [3]
RP FUNCTION.
RX PubMed=23446422; DOI=10.1038/nature11935;
RA Burrell R.A., McClelland S.E., Endesfelder D., Groth P., Weller M.C.,
RA Shaikh N., Domingo E., Kanu N., Dewhurst S.M., Gronroos E., Chew S.K.,
RA Rowan A.J., Schenk A., Sheffer M., Howell M., Kschischo M.,
RA Behrens A., Helleday T., Bartek J., Tomlinson I.P., Swanton C.;
RT "Replication stress links structural and numerical cancer chromosomal
RT instability.";
RL Nature 494:492-496(2013).
CC -!- FUNCTION: May be involved in transcriptional regulation. May act
CC as suppressor of replication stress and chromosome missegregation.
CC -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 10 C2H2-type zinc fingers.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA13211.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; D86975; BAA13211.2; ALT_INIT; mRNA.
DR RefSeq; NP_055458.1; NM_014643.3.
DR UniGene; Hs.436973; -.
DR ProteinModelPortal; Q92618; -.
DR SMR; Q92618; 34-84, 172-357, 508-546, 786-823, 1090-1135.
DR IntAct; Q92618; 5.
DR MINT; MINT-1728539; -.
DR STRING; 9606.ENSP00000394757; -.
DR PhosphoSite; Q92618; -.
DR DMDM; 14548318; -.
DR PaxDb; Q92618; -.
DR PRIDE; Q92618; -.
DR Ensembl; ENST00000443185; ENSP00000394757; ENSG00000101493.
DR GeneID; 9658; -.
DR KEGG; hsa:9658; -.
DR UCSC; uc021ulp.1; human.
DR CTD; 9658; -.
DR GeneCards; GC18M074071; -.
DR HGNC; HGNC:28990; ZNF516.
DR HPA; HPA015792; -.
DR MIM; 615114; gene.
DR neXtProt; NX_Q92618; -.
DR PharmGKB; PA134992707; -.
DR eggNOG; NOG316239; -.
DR HOGENOM; HOG000155800; -.
DR HOVERGEN; HBG079384; -.
DR InParanoid; Q92618; -.
DR OMA; WIQPNGY; -.
DR OrthoDB; EOG76471T; -.
DR GenomeRNAi; 9658; -.
DR NextBio; 36261; -.
DR PRO; PR:Q92618; -.
DR ArrayExpress; Q92618; -.
DR Bgee; Q92618; -.
DR CleanEx; HS_ZNF516; -.
DR Genevestigator; Q92618; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 5.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 10.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 1163 Zinc finger protein 516.
FT /FTId=PRO_0000047634.
FT ZN_FING 34 56 C2H2-type 1.
FT ZN_FING 62 84 C2H2-type 2.
FT ZN_FING 174 197 C2H2-type 3.
FT ZN_FING 200 223 C2H2-type 4.
FT ZN_FING 248 270 C2H2-type 5.
FT ZN_FING 276 298 C2H2-type 6.
FT ZN_FING 335 357 C2H2-type 7.
FT ZN_FING 515 537 C2H2-type 8.
FT ZN_FING 760 783 C2H2-type 9; atypical.
FT ZN_FING 1098 1120 C2H2-type 10.
FT VARIANT 4 4 N -> S (in dbSNP:rs3752097).
FT /FTId=VAR_052852.
FT VARIANT 239 239 G -> S (in dbSNP:rs12961584).
FT /FTId=VAR_052853.
SQ SEQUENCE 1163 AA; 124289 MW; 9D6DDDE2D70236A4 CRC64;
MDRNREAEME LRRGPSPTRA GRGHEVDGDK ATCHTCCICG KSFPFQSSLS QHMRKHTGEK
PYKCPYCDHR ASQKGNLKIH IRSHRTGTLI QGHEPEAGEA PLGEMRASEG LDACASPTKS
ASACNRLLNG ASQADGARVL NGASQADSGR VLLRSSKKGA EGSACAPGEA KAAVQCSFCK
SQFERKKDLE LHVHQAHKPF KCRLCSYATL REESLLSHIE RDHITAQGPG SGEACVENGK
PELSPGEFPC EVCGQAFSQT WFLKAHMKKH RGSFDHGCHI CGRRFKEPWF LKNHMKAHGP
KTGSKNRPKS ELDPIATINN VVQEEVIVAG LSLYEVCAKC GNLFTNLDSL NAHNAIHRRV
EASRTRAPAE EGAEGPSDTK QFFLQCLNLR PSAAGDSCPG TQAGRRVAEL DPVNSYQAWQ
LATRGKVAEP AEYLKYGAWD EALAGDVAFD KDRREYVLVS QEKRKREQDA PAAQGPPRKR
ASGPGDPAPA GHLDPRSAAR PNRRAAATTG QGKSSECFEC GKIFRTYHQM VLHSRVHRRA
RRERDSDGDR AARARCGSLS EGDSASQPSS PGSACAAADS PGSGLADEAA EDSGEEGAPE
PAPGGQPRRC CFSEEVTSTE LSSGDQSHKM GDNASERDTG ESKAGIAASV SILENSSRET
SRRQEQHRFS MDLKMPAFHP KQEVPVPGDG VEFPSSTGAE GQTGHPAEKL SDLHNKEHSG
GGKRALAPDL MPLDLSARST RDDPSNKETA SSLQAALVVH PCPYCSHKTY YPEVLWMHKR
IWHRVSCNSV APPWIQPNGY KSIRSNLVFL SRSGRTGPPP ALGGKECQPL LLARFTRTQV
PGGMPGSKSG SSPLGVVTKA ASMPKNKESH SGGPCALWAP GPDGYRQTKP CHGQEPHGAA
TQGPLAKPRQ EASSKPVPAP GGGGFSRSAT PTPTVIARAG AQPSANSKPV EKFGVPPAGA
GFAPTNKHSA PDSLKAKFSA QPQGPPPAKG EGGAPPLPPR EPPSKAAQEL RTLATCAAGS
RGDAALQAQP GVAGAPPVLH SIKQEPVAEG HEKRLDILNI FKTYIPKDFA TLYQGWGVSG
PGLEHRGTLR TQARPGEFVC IECGKSFHQP GHLRAHMRAH SVVFESDGPR GSEVHTTSAD
APKQGRDHSN TGTVQTVPLR KGT
//
ID ZN516_HUMAN Reviewed; 1163 AA.
AC Q92618;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-FEB-1997, sequence version 1.
DT 22-JAN-2014, entry version 117.
DE RecName: Full=Zinc finger protein 516;
GN Name=ZNF516; Synonyms=KIAA0222;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. VI.
RT The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by
RT analysis of cDNA clones from cell line KG-1 and brain.";
RL DNA Res. 3:321-329(1996).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [3]
RP FUNCTION.
RX PubMed=23446422; DOI=10.1038/nature11935;
RA Burrell R.A., McClelland S.E., Endesfelder D., Groth P., Weller M.C.,
RA Shaikh N., Domingo E., Kanu N., Dewhurst S.M., Gronroos E., Chew S.K.,
RA Rowan A.J., Schenk A., Sheffer M., Howell M., Kschischo M.,
RA Behrens A., Helleday T., Bartek J., Tomlinson I.P., Swanton C.;
RT "Replication stress links structural and numerical cancer chromosomal
RT instability.";
RL Nature 494:492-496(2013).
CC -!- FUNCTION: May be involved in transcriptional regulation. May act
CC as suppressor of replication stress and chromosome missegregation.
CC -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 10 C2H2-type zinc fingers.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA13211.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; D86975; BAA13211.2; ALT_INIT; mRNA.
DR RefSeq; NP_055458.1; NM_014643.3.
DR UniGene; Hs.436973; -.
DR ProteinModelPortal; Q92618; -.
DR SMR; Q92618; 34-84, 172-357, 508-546, 786-823, 1090-1135.
DR IntAct; Q92618; 5.
DR MINT; MINT-1728539; -.
DR STRING; 9606.ENSP00000394757; -.
DR PhosphoSite; Q92618; -.
DR DMDM; 14548318; -.
DR PaxDb; Q92618; -.
DR PRIDE; Q92618; -.
DR Ensembl; ENST00000443185; ENSP00000394757; ENSG00000101493.
DR GeneID; 9658; -.
DR KEGG; hsa:9658; -.
DR UCSC; uc021ulp.1; human.
DR CTD; 9658; -.
DR GeneCards; GC18M074071; -.
DR HGNC; HGNC:28990; ZNF516.
DR HPA; HPA015792; -.
DR MIM; 615114; gene.
DR neXtProt; NX_Q92618; -.
DR PharmGKB; PA134992707; -.
DR eggNOG; NOG316239; -.
DR HOGENOM; HOG000155800; -.
DR HOVERGEN; HBG079384; -.
DR InParanoid; Q92618; -.
DR OMA; WIQPNGY; -.
DR OrthoDB; EOG76471T; -.
DR GenomeRNAi; 9658; -.
DR NextBio; 36261; -.
DR PRO; PR:Q92618; -.
DR ArrayExpress; Q92618; -.
DR Bgee; Q92618; -.
DR CleanEx; HS_ZNF516; -.
DR Genevestigator; Q92618; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 5.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 10.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 1163 Zinc finger protein 516.
FT /FTId=PRO_0000047634.
FT ZN_FING 34 56 C2H2-type 1.
FT ZN_FING 62 84 C2H2-type 2.
FT ZN_FING 174 197 C2H2-type 3.
FT ZN_FING 200 223 C2H2-type 4.
FT ZN_FING 248 270 C2H2-type 5.
FT ZN_FING 276 298 C2H2-type 6.
FT ZN_FING 335 357 C2H2-type 7.
FT ZN_FING 515 537 C2H2-type 8.
FT ZN_FING 760 783 C2H2-type 9; atypical.
FT ZN_FING 1098 1120 C2H2-type 10.
FT VARIANT 4 4 N -> S (in dbSNP:rs3752097).
FT /FTId=VAR_052852.
FT VARIANT 239 239 G -> S (in dbSNP:rs12961584).
FT /FTId=VAR_052853.
SQ SEQUENCE 1163 AA; 124289 MW; 9D6DDDE2D70236A4 CRC64;
MDRNREAEME LRRGPSPTRA GRGHEVDGDK ATCHTCCICG KSFPFQSSLS QHMRKHTGEK
PYKCPYCDHR ASQKGNLKIH IRSHRTGTLI QGHEPEAGEA PLGEMRASEG LDACASPTKS
ASACNRLLNG ASQADGARVL NGASQADSGR VLLRSSKKGA EGSACAPGEA KAAVQCSFCK
SQFERKKDLE LHVHQAHKPF KCRLCSYATL REESLLSHIE RDHITAQGPG SGEACVENGK
PELSPGEFPC EVCGQAFSQT WFLKAHMKKH RGSFDHGCHI CGRRFKEPWF LKNHMKAHGP
KTGSKNRPKS ELDPIATINN VVQEEVIVAG LSLYEVCAKC GNLFTNLDSL NAHNAIHRRV
EASRTRAPAE EGAEGPSDTK QFFLQCLNLR PSAAGDSCPG TQAGRRVAEL DPVNSYQAWQ
LATRGKVAEP AEYLKYGAWD EALAGDVAFD KDRREYVLVS QEKRKREQDA PAAQGPPRKR
ASGPGDPAPA GHLDPRSAAR PNRRAAATTG QGKSSECFEC GKIFRTYHQM VLHSRVHRRA
RRERDSDGDR AARARCGSLS EGDSASQPSS PGSACAAADS PGSGLADEAA EDSGEEGAPE
PAPGGQPRRC CFSEEVTSTE LSSGDQSHKM GDNASERDTG ESKAGIAASV SILENSSRET
SRRQEQHRFS MDLKMPAFHP KQEVPVPGDG VEFPSSTGAE GQTGHPAEKL SDLHNKEHSG
GGKRALAPDL MPLDLSARST RDDPSNKETA SSLQAALVVH PCPYCSHKTY YPEVLWMHKR
IWHRVSCNSV APPWIQPNGY KSIRSNLVFL SRSGRTGPPP ALGGKECQPL LLARFTRTQV
PGGMPGSKSG SSPLGVVTKA ASMPKNKESH SGGPCALWAP GPDGYRQTKP CHGQEPHGAA
TQGPLAKPRQ EASSKPVPAP GGGGFSRSAT PTPTVIARAG AQPSANSKPV EKFGVPPAGA
GFAPTNKHSA PDSLKAKFSA QPQGPPPAKG EGGAPPLPPR EPPSKAAQEL RTLATCAAGS
RGDAALQAQP GVAGAPPVLH SIKQEPVAEG HEKRLDILNI FKTYIPKDFA TLYQGWGVSG
PGLEHRGTLR TQARPGEFVC IECGKSFHQP GHLRAHMRAH SVVFESDGPR GSEVHTTSAD
APKQGRDHSN TGTVQTVPLR KGT
//
MIM
615114
*RECORD*
*FIELD* NO
615114
*FIELD* TI
*615114 ZINC FINGER PROTEIN 516; ZNF516
;;KIAA0222
*FIELD* TX
CLONING
By sequencing clones obtained from a size-fractionated KG-1 human
read moreimmature myeloid cell line cDNA library, Nagase et al. (1996) cloned
ZNF516, which they designated KIAA0222. The deduced 1,163-amino acid
protein contains 7 C2H2-type zinc finger repeats and an ATP/GTP-binding
site motif A (P loop). Northern blot analysis detected moderate ZNF516
expression in testis and low expression in all other adult tissues
examined except colon.
GENE FUNCTION
Burrell et al. (2013) found evidence for impaired replication fork
progression and increased DNA replication stress in cancer chromosomal
instability (CIN)+ colorectal cancer cells relative to CIN- colorectal
cancer cells, with structural chromosome abnormalities precipitating
chromosome missegregation in mitosis. Burrell et al. (2013) identified 3
CIN suppressor genes (PIGN, 606097; MEX3C, 611005; and ZNF516) encoded
on chromosome 18q that are subject to frequent copy number loss in CIN+
colorectal cancer cells. Chromosome 18q loss was temporally associated
with aneuploidy onset at the adenoma-carcinoma transition. CIN
suppressor gene silencing led to DNA replication stress, structural
chromosome abnormalities, and chromosome missegregation. Supplementing
cells with nucleosides, to alleviate replication-associated damage,
reduced the frequency of chromosome segregation errors after CIN
suppressor gene silencing, and attenuated segregation errors and DNA
damage in CIN+ cells. Burrell et al. (2013) concluded that their data
implicated a central role for replication stress in the generation of
structural and numerical CIN.
MAPPING
By radiation hybrid analysis, Nagase et al. (1996) mapped the ZNF516
gene to chromosome 18.
Hartz (2013) mapped the ZNF516 gene to chromosome 18q23 based on an
alignment of the ZNF516 sequence (GenBank GENBANK D86975) with the
genomic sequence (GRCh37).
*FIELD* RF
1. Burrell, R. A.; McClelland, S. E.; Endesfelder, D.; Groth, P.;
Weller, M.-C.; Shaikh, N.; Domingo, E.; Kanu, N.; Dewhurst, S. M.;
Gronroos, E.; Chew, S. K.; Rowan, A. J.; and 9 others: Replication
stress links structural and numerical cancer chromosomal instability. Nature 494:
492-496, 2013. Note: Erratum: Nature 500: 490 only, 2013.
2. Hartz, P. A.: Personal Communication. Baltimore, Md. 3/7/2013.
3. Nagase, T.; Seki, N.; Ishikawa, K.; Ohira, M.; Kawarabayasi, Y.;
Ohara, O.; Tanaka, A.; Kotani, H.; Miyajima, N.; Nomura, N.: Prediction
of the coding sequences of unidentified human genes. VI. The coding
sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis
of cDNA clones from cell line KG-1 and brain. DNA Res. 3: 321-329,
1996.
*FIELD* CN
Ada Hamosh - updated: 3/8/2013
*FIELD* CD
Patricia A. Hartz: 3/7/2013
*FIELD* ED
mgross: 10/09/2013
alopez: 3/8/2013
mgross: 3/7/2013
*RECORD*
*FIELD* NO
615114
*FIELD* TI
*615114 ZINC FINGER PROTEIN 516; ZNF516
;;KIAA0222
*FIELD* TX
CLONING
By sequencing clones obtained from a size-fractionated KG-1 human
read moreimmature myeloid cell line cDNA library, Nagase et al. (1996) cloned
ZNF516, which they designated KIAA0222. The deduced 1,163-amino acid
protein contains 7 C2H2-type zinc finger repeats and an ATP/GTP-binding
site motif A (P loop). Northern blot analysis detected moderate ZNF516
expression in testis and low expression in all other adult tissues
examined except colon.
GENE FUNCTION
Burrell et al. (2013) found evidence for impaired replication fork
progression and increased DNA replication stress in cancer chromosomal
instability (CIN)+ colorectal cancer cells relative to CIN- colorectal
cancer cells, with structural chromosome abnormalities precipitating
chromosome missegregation in mitosis. Burrell et al. (2013) identified 3
CIN suppressor genes (PIGN, 606097; MEX3C, 611005; and ZNF516) encoded
on chromosome 18q that are subject to frequent copy number loss in CIN+
colorectal cancer cells. Chromosome 18q loss was temporally associated
with aneuploidy onset at the adenoma-carcinoma transition. CIN
suppressor gene silencing led to DNA replication stress, structural
chromosome abnormalities, and chromosome missegregation. Supplementing
cells with nucleosides, to alleviate replication-associated damage,
reduced the frequency of chromosome segregation errors after CIN
suppressor gene silencing, and attenuated segregation errors and DNA
damage in CIN+ cells. Burrell et al. (2013) concluded that their data
implicated a central role for replication stress in the generation of
structural and numerical CIN.
MAPPING
By radiation hybrid analysis, Nagase et al. (1996) mapped the ZNF516
gene to chromosome 18.
Hartz (2013) mapped the ZNF516 gene to chromosome 18q23 based on an
alignment of the ZNF516 sequence (GenBank GENBANK D86975) with the
genomic sequence (GRCh37).
*FIELD* RF
1. Burrell, R. A.; McClelland, S. E.; Endesfelder, D.; Groth, P.;
Weller, M.-C.; Shaikh, N.; Domingo, E.; Kanu, N.; Dewhurst, S. M.;
Gronroos, E.; Chew, S. K.; Rowan, A. J.; and 9 others: Replication
stress links structural and numerical cancer chromosomal instability. Nature 494:
492-496, 2013. Note: Erratum: Nature 500: 490 only, 2013.
2. Hartz, P. A.: Personal Communication. Baltimore, Md. 3/7/2013.
3. Nagase, T.; Seki, N.; Ishikawa, K.; Ohira, M.; Kawarabayasi, Y.;
Ohara, O.; Tanaka, A.; Kotani, H.; Miyajima, N.; Nomura, N.: Prediction
of the coding sequences of unidentified human genes. VI. The coding
sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis
of cDNA clones from cell line KG-1 and brain. DNA Res. 3: 321-329,
1996.
*FIELD* CN
Ada Hamosh - updated: 3/8/2013
*FIELD* CD
Patricia A. Hartz: 3/7/2013
*FIELD* ED
mgross: 10/09/2013
alopez: 3/8/2013
mgross: 3/7/2013