Full text data of ZPBP
ZPBP
(ZPBP1)
[Confidence: low (only semi-automatic identification from reviews)]
Zona pellucida-binding protein 1 (Sp38; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Zona pellucida-binding protein 1 (Sp38; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9BS86
ID ZPBP1_HUMAN Reviewed; 351 AA.
AC Q9BS86; A4D253; C9JPU1; Q15941; Q75KX9; Q75MI3;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 89.
DE RecName: Full=Zona pellucida-binding protein 1;
DE AltName: Full=Sp38;
DE Flags: Precursor;
GN Name=ZPBP; Synonyms=ZPBP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Baba T., Mori E., Mori T., Kashiwabara S., Tanaka K.;
RT "Expression of the gene encoding zona-pellucida-binding protein, sp38,
RT during spermatogenesis.";
RL Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA Mural R.J., Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP REVIEW.
RX PubMed=9378618;
RA McLeskey S.B., Dowds C., Carballada R., White R.R., Saling P.M.;
RT "Molecules involved in mammalian sperm-egg interaction.";
RL Int. Rev. Cytol. 177:57-113(1998).
CC -!- FUNCTION: May be implicated in gamete interaction during
CC fertilization.
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BS86-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BS86-2; Sequence=VSP_045491;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the zona pellucida-binding protein Sp38
CC family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS07517.1; Type=Erroneous initiation;
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DR EMBL; D17570; BAA04495.1; -; mRNA.
DR EMBL; BT006822; AAP35468.1; -; mRNA.
DR EMBL; AK312799; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC020743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC034145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC096568; AAS07517.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC034148; AAS07558.1; -; Genomic_DNA.
DR EMBL; CH236955; EAL23903.1; -; Genomic_DNA.
DR EMBL; CH471128; EAW60984.1; -; Genomic_DNA.
DR EMBL; BC005223; AAH05223.1; -; mRNA.
DR RefSeq; NP_001153350.1; NM_001159878.1.
DR RefSeq; NP_008940.2; NM_007009.2.
DR UniGene; Hs.388841; -.
DR ProteinModelPortal; Q9BS86; -.
DR IntAct; Q9BS86; 1.
DR MINT; MINT-4723516; -.
DR STRING; 9606.ENSP00000046087; -.
DR PhosphoSite; Q9BS86; -.
DR DMDM; 54036652; -.
DR PaxDb; Q9BS86; -.
DR PRIDE; Q9BS86; -.
DR DNASU; 11055; -.
DR Ensembl; ENST00000046087; ENSP00000046087; ENSG00000042813.
DR Ensembl; ENST00000419417; ENSP00000402071; ENSG00000042813.
DR GeneID; 11055; -.
DR KEGG; hsa:11055; -.
DR UCSC; uc010kyw.3; human.
DR CTD; 11055; -.
DR GeneCards; GC07M049947; -.
DR HGNC; HGNC:15662; ZPBP.
DR MIM; 608498; gene.
DR neXtProt; NX_Q9BS86; -.
DR PharmGKB; PA38013; -.
DR eggNOG; NOG41092; -.
DR HOGENOM; HOG000230972; -.
DR HOVERGEN; HBG106672; -.
DR InParanoid; Q9BS86; -.
DR OMA; CNSSLVY; -.
DR OrthoDB; EOG7D2FF2; -.
DR PhylomeDB; Q9BS86; -.
DR GenomeRNAi; 11055; -.
DR NextBio; 42003; -.
DR PRO; PR:Q9BS86; -.
DR ArrayExpress; Q9BS86; -.
DR Bgee; Q9BS86; -.
DR CleanEx; HS_ZPBP; -.
DR Genevestigator; Q9BS86; -.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0002199; C:zona pellucida receptor complex; IEA:Ensembl.
DR GO; GO:0001675; P:acrosome assembly; IEA:Ensembl.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:Ensembl.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010857; Sp38-bd.
DR PANTHER; PTHR15443; PTHR15443; 1.
DR Pfam; PF07354; Sp38; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 44 Potential.
FT CHAIN 45 351 Zona pellucida-binding protein 1.
FT /FTId=PRO_0000041598.
FT CARBOHYD 114 114 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 187 187 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 340 340 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 112 112 Missing (in isoform 2).
FT /FTId=VSP_045491.
FT CONFLICT 180 180 A -> V (in Ref. 1; BAA04495).
SQ SEQUENCE 351 AA; 40142 MW; 8B57027FBE12E7DB CRC64;
MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP RAFRLTKDSV
KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF QWYGPKGKVV SVENRTAQIT
STGSLVFQNF EESMSGIYTC FLEYKPTVEE IVKRLQLKYA IYAYREPHYY YQFTARYHAA
PCNSIYNISF EKKLLQILSK LLLDLSCEIS LLKSECHRVK MQRAGLQNEL FFAFSVSSLD
TEKGPKRCTD HNCEPYKRLF KAKNLIERFF NQQVEILGRR AEQLPQIYYI EGTLQMVWIN
RCFPGYGMNV QQHPKCPECC VICSPGSYNP RDGIHCLQCN SSLVYGAKTC L
//
ID ZPBP1_HUMAN Reviewed; 351 AA.
AC Q9BS86; A4D253; C9JPU1; Q15941; Q75KX9; Q75MI3;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 89.
DE RecName: Full=Zona pellucida-binding protein 1;
DE AltName: Full=Sp38;
DE Flags: Precursor;
GN Name=ZPBP; Synonyms=ZPBP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Baba T., Mori E., Mori T., Kashiwabara S., Tanaka K.;
RT "Expression of the gene encoding zona-pellucida-binding protein, sp38,
RT during spermatogenesis.";
RL Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA Mural R.J., Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP REVIEW.
RX PubMed=9378618;
RA McLeskey S.B., Dowds C., Carballada R., White R.R., Saling P.M.;
RT "Molecules involved in mammalian sperm-egg interaction.";
RL Int. Rev. Cytol. 177:57-113(1998).
CC -!- FUNCTION: May be implicated in gamete interaction during
CC fertilization.
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BS86-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BS86-2; Sequence=VSP_045491;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the zona pellucida-binding protein Sp38
CC family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS07517.1; Type=Erroneous initiation;
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DR EMBL; D17570; BAA04495.1; -; mRNA.
DR EMBL; BT006822; AAP35468.1; -; mRNA.
DR EMBL; AK312799; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC020743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC034145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC096568; AAS07517.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC034148; AAS07558.1; -; Genomic_DNA.
DR EMBL; CH236955; EAL23903.1; -; Genomic_DNA.
DR EMBL; CH471128; EAW60984.1; -; Genomic_DNA.
DR EMBL; BC005223; AAH05223.1; -; mRNA.
DR RefSeq; NP_001153350.1; NM_001159878.1.
DR RefSeq; NP_008940.2; NM_007009.2.
DR UniGene; Hs.388841; -.
DR ProteinModelPortal; Q9BS86; -.
DR IntAct; Q9BS86; 1.
DR MINT; MINT-4723516; -.
DR STRING; 9606.ENSP00000046087; -.
DR PhosphoSite; Q9BS86; -.
DR DMDM; 54036652; -.
DR PaxDb; Q9BS86; -.
DR PRIDE; Q9BS86; -.
DR DNASU; 11055; -.
DR Ensembl; ENST00000046087; ENSP00000046087; ENSG00000042813.
DR Ensembl; ENST00000419417; ENSP00000402071; ENSG00000042813.
DR GeneID; 11055; -.
DR KEGG; hsa:11055; -.
DR UCSC; uc010kyw.3; human.
DR CTD; 11055; -.
DR GeneCards; GC07M049947; -.
DR HGNC; HGNC:15662; ZPBP.
DR MIM; 608498; gene.
DR neXtProt; NX_Q9BS86; -.
DR PharmGKB; PA38013; -.
DR eggNOG; NOG41092; -.
DR HOGENOM; HOG000230972; -.
DR HOVERGEN; HBG106672; -.
DR InParanoid; Q9BS86; -.
DR OMA; CNSSLVY; -.
DR OrthoDB; EOG7D2FF2; -.
DR PhylomeDB; Q9BS86; -.
DR GenomeRNAi; 11055; -.
DR NextBio; 42003; -.
DR PRO; PR:Q9BS86; -.
DR ArrayExpress; Q9BS86; -.
DR Bgee; Q9BS86; -.
DR CleanEx; HS_ZPBP; -.
DR Genevestigator; Q9BS86; -.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0002199; C:zona pellucida receptor complex; IEA:Ensembl.
DR GO; GO:0001675; P:acrosome assembly; IEA:Ensembl.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:Ensembl.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010857; Sp38-bd.
DR PANTHER; PTHR15443; PTHR15443; 1.
DR Pfam; PF07354; Sp38; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 44 Potential.
FT CHAIN 45 351 Zona pellucida-binding protein 1.
FT /FTId=PRO_0000041598.
FT CARBOHYD 114 114 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 187 187 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 340 340 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 112 112 Missing (in isoform 2).
FT /FTId=VSP_045491.
FT CONFLICT 180 180 A -> V (in Ref. 1; BAA04495).
SQ SEQUENCE 351 AA; 40142 MW; 8B57027FBE12E7DB CRC64;
MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP RAFRLTKDSV
KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF QWYGPKGKVV SVENRTAQIT
STGSLVFQNF EESMSGIYTC FLEYKPTVEE IVKRLQLKYA IYAYREPHYY YQFTARYHAA
PCNSIYNISF EKKLLQILSK LLLDLSCEIS LLKSECHRVK MQRAGLQNEL FFAFSVSSLD
TEKGPKRCTD HNCEPYKRLF KAKNLIERFF NQQVEILGRR AEQLPQIYYI EGTLQMVWIN
RCFPGYGMNV QQHPKCPECC VICSPGSYNP RDGIHCLQCN SSLVYGAKTC L
//
MIM
608498
*RECORD*
*FIELD* NO
608498
*FIELD* TI
*608498 ZONA PELLUCIDA-BINDING PROTEIN; ZPBP
;;SP38
*FIELD* TX
DESCRIPTION
ZPBP is one of several proteins that are thought to participate in
read moresecondary binding between acrosome-reacted sperm and the egg-specific
extracellular matrix, the zona pellucida (McLeskey et al., 1998).
CLONING
Katoh and Katoh (2003) determined that the deduced 351-amino acid ZPBP
protein has no N-terminal signal peptide, but contains an N-terminal
transmembrane domain and a long extracellular domain of almost 300 amino
acids. The extracellular domain shares 38.1% identity with a homologous
domain within ZPBP2 (608499), including 15 conserved Cys residues.
Analysis of EST databases indicated that ZPBP mRNA was coexpressed with
ZPBP2 mRNA in testis, germ cell tumor, and brain medulla.
MAPPING
Katoh and Katoh (2003) stated that the ZPBP gene maps to chromosome
7p12. Other genes at this locus include ZNFN1A1 (603023), GRB10
(601523), and EGFR (131550). Comparative genomics revealed that this
locus is paralogous to the locus on chromosome 17q that contains ZPBP2.
*FIELD* RF
1. Katoh, M.; Katoh, M.: Identification and characterization of human
ZPBP-like gene in silico. Int. J. Molec. Med. 12: 399-404, 2003.
2. McLeskey, S. B.; Dowds, C.; Carballada, R.; White, R. R.; Saling,
P. M.: Molecules involved in mammalian sperm-egg interaction. Int.
Rev. Cytol. 177: 57-113, 1998.
*FIELD* CD
Patricia A. Hartz: 2/27/2004
*FIELD* ED
alopez: 02/27/2004
*RECORD*
*FIELD* NO
608498
*FIELD* TI
*608498 ZONA PELLUCIDA-BINDING PROTEIN; ZPBP
;;SP38
*FIELD* TX
DESCRIPTION
ZPBP is one of several proteins that are thought to participate in
read moresecondary binding between acrosome-reacted sperm and the egg-specific
extracellular matrix, the zona pellucida (McLeskey et al., 1998).
CLONING
Katoh and Katoh (2003) determined that the deduced 351-amino acid ZPBP
protein has no N-terminal signal peptide, but contains an N-terminal
transmembrane domain and a long extracellular domain of almost 300 amino
acids. The extracellular domain shares 38.1% identity with a homologous
domain within ZPBP2 (608499), including 15 conserved Cys residues.
Analysis of EST databases indicated that ZPBP mRNA was coexpressed with
ZPBP2 mRNA in testis, germ cell tumor, and brain medulla.
MAPPING
Katoh and Katoh (2003) stated that the ZPBP gene maps to chromosome
7p12. Other genes at this locus include ZNFN1A1 (603023), GRB10
(601523), and EGFR (131550). Comparative genomics revealed that this
locus is paralogous to the locus on chromosome 17q that contains ZPBP2.
*FIELD* RF
1. Katoh, M.; Katoh, M.: Identification and characterization of human
ZPBP-like gene in silico. Int. J. Molec. Med. 12: 399-404, 2003.
2. McLeskey, S. B.; Dowds, C.; Carballada, R.; White, R. R.; Saling,
P. M.: Molecules involved in mammalian sperm-egg interaction. Int.
Rev. Cytol. 177: 57-113, 1998.
*FIELD* CD
Patricia A. Hartz: 2/27/2004
*FIELD* ED
alopez: 02/27/2004