1433B_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: YWHAB
Protein names and data: 1433B_HUMAN , 14-3-3 protein beta/alpha , Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1; 14-3-3 protein beta/alpha, N-terminally processed Lenght: 246 a.a.
Mass: 28082 Da
fasta formatted sequence
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
Cellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Genetic variants

Database cross-references

UniProt: P31946
Ensembl: ENST00000353703
Ensembl: ENST00000372839
MIM: 601289
neXtProt: NX_P31946
Antibodypedia: P31946 (may not find the protein thus also not any antibody)
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