1433S_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SFN , HME1
Protein names and data: 1433S_HUMAN , 14-3-3 protein sigma , Epithelial cell marker protein 1; Stratifin Lenght: 248 a.a.
Mass: 27774 Da
fasta formatted sequence
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
Cellular location: Cytoplasm. Nucleus (By similarity). Secreted. Note=May be secreted by a non-classical secretory pathway.
Tissue specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Genetic variants

Database cross-references

UniProt: P31947
Ensembl: ENST00000339276
MIM: 601290
neXtProt: NX_P31947
Antibodypedia: P31947 (may not find the protein thus also not any antibody)
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