1433T_HUMAN

Source: hRBCD ; ID: IPI00018146
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: YWHAQ
Protein names and data: 1433T_HUMAN , 14-3-3 protein theta , 14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1 Lenght: 245 a.a.
Mass: 27764 Da
fasta formatted sequence
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Cellular location: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.
Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.

Database cross-references

UniProt: P27348
Ensembl: ENST00000238081
Ensembl: ENST00000381844
MIM: 609009
neXtProt: NX_P27348
Antibodypedia: P27348 (may not find the protein thus also not any antibody)
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