1B07_HUMAN
Source:
BSc_CH
Marked as 'Integral membrane protein'
Confidence:
medium (present in either hRBCD or BSc_CH or PM22954596)
Search PubMed for
(RBC AND this entry)
Gene names:
HLA-B
, HLAB
Protein names and data:
1B07_HUMAN
, HLA class I histocompatibility antigen, B-7 alpha chain
, MHC class I antigen B*7; Flags: Precursor
Lenght: 362 a.a.
Mass: 40460 Da
fasta formatted sequence
Function:
Involved in the presentation of foreign antigens to the immune system.
Cellular location:
Membrane; Single-pass type I membrane protein.
Genetic variants
The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02.
4 - 4
M -> T (in dbSNP:rs1050458). VAR_050332
1050458
9 - 9
V -> L (in dbSNP:rs1050462). VAR_050333
1050462
17 - 17
L -> V (in dbSNP:rs1131165). VAR_050334
1131165
35 - 35
S -> A (in dbSNP:rs1131170). VAR_050335
1131170
36 - 36
V -> M (in dbSNP:rs1050486). VAR_050336
1050486
48 - 48
S -> A (in dbSNP:rs713031). VAR_061386
713031
48 - 48
S -> P (in dbSNP:rs713031). VAR_061387
713031
48 - 48
S -> T (in dbSNP:rs713031). VAR_061388
713031
65 - 65
A -> T (in dbSNP:rs1050529). VAR_050337
1050529
87 - 87
N -> D (in dbSNP:rs1050570). VAR_050338
1050570
87 - 87
N -> K (in dbSNP:rs1065386). VAR_059467
1065386
93 - 95
AQA -> TNT (in allele B*07:03). VAR_016351
97 - 97
T -> A (in dbSNP:rs1050393). VAR_050339
1050393
98 - 98
D -> Y (in dbSNP:rs1131215). VAR_059468
1131215
101 - 101
S -> N (in dbSNP:rs1050388). VAR_050340
1050388
118 - 119
TL -> II (in allele B*07:18). VAR_016352
121 - 121
S -> R (in allele B*07:18). VAR_016353
137 - 137
H -> Y (in dbSNP:rs1050379). VAR_050341
1050379
138 - 138
D -> H (in dbSNP:rs709055). VAR_061389
709055
138 - 138
D -> N (in allele B*07:05 and allele B*07:06; dbSNP:rs709055). VAR_016354
709055
155 - 155
R -> S (in dbSNP:rs1050654). VAR_050342
1050654
180 - 180
R -> D (in allele B*07:04; requires 2 nucleotide substitutions). VAR_016355
187 - 187
E -> A (in dbSNP:rs2308466). VAR_059469
2308466
187 - 187
E -> G (in dbSNP:rs2308466). VAR_059470
2308466
187 - 187
E -> K (in dbSNP:rs2523600). VAR_059471
2523600
187 - 187
E -> L (in allele B*07:24; requires 2 nucleotide substitutions). VAR_016616
187 - 187
E -> Q (in dbSNP:rs2523600). VAR_059472
2523600
187 - 187
E -> V (in dbSNP:rs2308466). VAR_059473
2308466
195 - 195
Y -> H (in dbSNP:rs1050696). VAR_050343
1050696
306 - 306
V -> I (in allele B*07:05; dbSNP:rs1131500). VAR_016356
1131500
329 - 329
A -> T (in dbSNP:rs1051488). VAR_050344
1051488
349 - 349
C -> S (in dbSNP:rs2308655). VAR_061390
2308655
349 - 349
C -> Y (in dbSNP:rs2308655). VAR_061391
2308655
Database cross-references
UniProt:
P01889
Ensembl:
ENST00000412585
MIM:
142830
neXtProt:
NX_P01889
Antibodypedia:
P01889
(may not find the protein thus also not any antibody)
Local full text data:
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