A2ML1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: A2ML1 , CPAMD9
Protein names and data: A2ML1_HUMAN , Alpha-2-macroglobulin-like protein 1 , C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9; Flags: Precursor Lenght: 1454 a.a.
Mass: 161107 Da
fasta formatted sequence
Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
Cellular location: Secreted.
Tissue specificity: In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.

Genetic variants

Database cross-references

UniProt: A8K2U0
Ensembl: ENST00000299698
MIM: 610627
neXtProt: NX_A8K2U0
Antibodypedia: A8K2U0 (may not find the protein thus also not any antibody)
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