AAKB1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PRKAB1 , AMPK
Protein names and data: AAKB1_HUMAN , 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb Lenght: 270 a.a.
Mass: 30382 Da
fasta formatted sequence
Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Database cross-references

UniProt: Q9Y478
Ensembl: ENST00000229328
Ensembl: ENST00000541640
MIM: 602740
neXtProt: NX_Q9Y478
Antibodypedia: Q9Y478 (may not find the protein thus also not any antibody)
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