AATC_HUMAN

Source: hRBCD ; ID: IPI00219029
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: GOT1
Protein names and data: AATC_HUMAN , Aspartate aminotransferase, cytoplasmic; cAspAT; 2.6.1.1; 2.6.1.3 , Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A Lenght: 413 a.a.
Mass: 46248 Da
fasta formatted sequence
Function: Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
Cellular location: Cytoplasm.

Genetic variants

Genetic variations in GOT1 are associated with low serum aspartate aminotransferase and define the aspartate aminotransferase serum level quantitative trait locus 1 (ASTQTL1) [MIM:614419].

Database cross-references

UniProt: P17174
Ensembl: ENST00000370508
MIM: 138180
MIM: 614419
neXtProt: NX_P17174
Antibodypedia: P17174 (may not find the protein thus also not any antibody)
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