AATM_HUMAN

Source: BSc_CH
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: GOT2
Protein names and data: AATM_HUMAN , Aspartate aminotransferase, mitochondrial; mAspAT; 2.6.1.1; 2.6.1.7 , Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A; Flags: Precursor Lenght: 430 a.a.
Mass: 47518 Da
fasta formatted sequence
Function: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. L-kynurenine + 2-oxoglutarate = 4-(2- aminophenyl)-2,4-dioxobutanoate + L-glutamate.
Cellular location: Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the cell membrane.

Genetic variants

Database cross-references

UniProt: P00505
Ensembl: ENST00000245206
MIM: 138150
neXtProt: NX_P00505
Antibodypedia: P00505 (may not find the protein thus also not any antibody)
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