ABC3B_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: APOBEC3B
Protein names and data: ABC3B_HUMAN , DNA dC->dU-editing enzyme APOBEC-3B; A3B; 3.5.4.- , Phorbolin-1-related protein; Phorbolin-2/3 Lenght: 382 a.a.
Mass: 45924 Da
fasta formatted sequence
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T- cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Catalytic activity: Cytidine + H(2)O = uridine + NH(3).
Cellular location: Nucleus.
Tissue specificity: Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues.

Genetic variants

Database cross-references

UniProt: Q9UH17
Ensembl: ENST00000333467
Ensembl: ENST00000335760
Ensembl: ENST00000407298
MIM: 607110
neXtProt: NX_Q9UH17
Antibodypedia: Q9UH17 (may not find the protein thus also not any antibody)
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