ABCA7_HUMAN

Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ABCA7
Protein names and data: ABCA7_HUMAN , ATP-binding cassette sub-family A member 7 , ABCA-SSN; Autoantigen SS-N; Macrophage ABC transporter Lenght: 2146 a.a.
Mass: 234350 Da
fasta formatted sequence
Function: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.
Cellular location: Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. Isoform 2 may localize to the endoplasmic reticulum.
Tissue specificity: Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow.

Genetic variants

Database cross-references

UniProt: Q8IZY2
Ensembl: ENST00000263094
Ensembl: ENST00000433129
Ensembl: ENST00000435683
MIM: 605414
neXtProt: NX_Q8IZY2
Antibodypedia: Q8IZY2 (may not find the protein thus also not any antibody)
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