ACOC_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ACO1 , IREB1
Protein names and data: ACOC_HUMAN , Cytoplasmic aconitate hydratase; Aconitase; 4.2.1.3 , Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1 Lenght: 889 a.a.
Mass: 98399 Da
fasta formatted sequence
Function: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
Catalytic activity: Citrate = isocitrate.
Cellular location: Cytoplasm.

Genetic variants

Database cross-references

UniProt: P21399
Ensembl: ENST00000309951
Ensembl: ENST00000379923
MIM: 100880
neXtProt: NX_P21399
Antibodypedia: P21399 (may not find the protein thus also not any antibody)
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