ACSL1_HUMAN

Source: hRBCD ; ID: IPI00012728
PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ACSL1 , FACL1, FACL2, LACS, LACS1, LACS2
Protein names and data: ACSL1_HUMAN , Long-chain-fatty-acid--CoA ligase 1; 6.2.1.3 , Acyl-CoA synthetase 1; ACS1; Long-chain acyl-CoA synthetase 1; LACS 1; Long-chain acyl-CoA synthetase 2; LACS 2; Long-chain fatty acid-CoA ligase 2; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2 Lenght: 698 a.a.
Mass: 77943 Da
fasta formatted sequence
Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cellular location: Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity).
Tissue specificity: Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.

Database cross-references

UniProt: P33121
Ensembl: ENST00000281455
Ensembl: ENST00000504342
Ensembl: ENST00000515030
MIM: 152425
neXtProt: NX_P33121
Antibodypedia: P33121 (may not find the protein thus also not any antibody)
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