ACSL3_HUMAN

Source: hRBCD ; ID: IPI00031397
PM19886704
PM23856902
BSc_CH
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: ACSL3 , ACS3, FACL3, LACS3
Protein names and data: ACSL3_HUMAN , Long-chain-fatty-acid--CoA ligase 3; 6.2.1.3 , Long-chain acyl-CoA synthetase 3; LACS 3 Lenght: 720 a.a.
Mass: 80420 Da
fasta formatted sequence
Function: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).
Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cellular location: Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity).

Genetic variants

Database cross-references

UniProt: O95573
Ensembl: ENST00000357430
Ensembl: ENST00000392066
MIM: 602371
neXtProt: NX_O95573
Antibodypedia: O95573 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.