ACSL6_HUMAN

Source: PM19886704
PM23856902
BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ACSL6 , ACS2, FACL6, KIAA0837, LACS5
Protein names and data: ACSL6_HUMAN , Long-chain-fatty-acid--CoA ligase 6; 6.2.1.3 , Long-chain acyl-CoA synthetase 6; LACS 6 Lenght: 697 a.a.
Mass: 77752 Da
fasta formatted sequence
Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Disease:
Cellular location: Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity).
Tissue specificity: Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.

Database cross-references

UniProt: Q9UKU0
Ensembl: ENST00000296869
Ensembl: ENST00000357096
Ensembl: ENST00000379240
Ensembl: ENST00000379244
Ensembl: ENST00000379246
Ensembl: ENST00000379249
Ensembl: ENST00000379255
Ensembl: ENST00000379264
Ensembl: ENST00000379272
Ensembl: ENST00000413683
Ensembl: ENST00000543479
MIM: 604443
neXtProt: NX_Q9UKU0
Antibodypedia: Q9UKU0 (may not find the protein thus also not any antibody)
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