Source: hRBCD ; ID: IPI00019904
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: ADD2 , ADDB
Protein names and data: ADDB_HUMAN , Beta-adducin , Erythrocyte adducin subunit beta Lenght: 726 a.a.
Mass: 80854 Da
fasta formatted sequence

Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
Cellular location: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue specificity: Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.

Genetic variants

Database cross-references

UniProt: P35612
Ensembl: ENST00000264436
Ensembl: ENST00000355733
Ensembl: ENST00000403045
Ensembl: ENST00000407644
Ensembl: ENST00000413157
Ensembl: ENST00000430656
Ensembl: ENST00000522886
Ensembl: ENST00000606038
Ensembl: ENST00000606120
Ensembl: ENST00000606312
Ensembl: ENST00000606698
Ensembl: ENST00000607267
Ensembl: ENST00000607524
Ensembl: ENST00000607677
MIM: 102681
neXtProt: NX_P35612
Antibodypedia: P35612 (may not find the protein thus also not any antibody)
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