AGO1_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: AGO1 , EIF2C1
Protein names and data: AGO1_HUMAN , Protein argonaute-1; Argonaute1; hAgo1 , Argonaute RISC catalytic component 1; Eukaryotic translation initiation factor 2C 1; eIF-2C 1; eIF2C 1; Putative RNA-binding protein Q99 Lenght: 857 a.a.
Mass: 97214 Da
fasta formatted sequence
Function: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).
Cellular location: Cytoplasm, P-body.

Database cross-references

UniProt: Q9UL18
Ensembl: ENST00000373204
MIM: 606228
neXtProt: NX_Q9UL18
Antibodypedia: Q9UL18 (may not find the protein thus also not any antibody)
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