AK1A1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: AKR1A1 , ALDR1, ALR
Protein names and data: AK1A1_HUMAN , Alcohol dehydrogenase [NADP(+)]; 1.1.1.2 , Aldehyde reductase; Aldo-keto reductase family 1 member A1 Lenght: 325 a.a.
Mass: 36573 Da
fasta formatted sequence
Function: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Catalytic activity: An alcohol + NADP(+) = an aldehyde + NADPH.
Tissue specificity: Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.

Genetic variants

Database cross-references

UniProt: P14550
Ensembl: ENST00000351829
Ensembl: ENST00000372070
MIM: 103830
neXtProt: NX_P14550
Antibodypedia: P14550 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.