AK1C1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: AKR1C1 , DDH, DDH1
Protein names and data: AK1C1_HUMAN , Aldo-keto reductase family 1 member C1; 1.1.1.- , 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 1.1.1.149; Chlordecone reductase homolog HAKRC; Dihydrodiol dehydrogenase 1/2; DD1/DD2; High-affinity hepatic bile acid-binding protein; HBAB; Indanol dehydrogenase; 1.1.1.112; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; 1.3.1.20 Lenght: 323 a.a.
Mass: 36788 Da
fasta formatted sequence
Function: Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
Catalytic activity: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha-hydroxyprogesterone + NAD(P)H. Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH. Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.
Cellular location: Cytoplasm.
Tissue specificity: Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.

Genetic variants

Database cross-references

UniProt: Q04828
Ensembl: ENST00000380872
Ensembl: ENST00000434459
Ensembl: ENST00000578362
Ensembl: ENST00000582412
MIM: 600449
neXtProt: NX_Q04828
Antibodypedia: Q04828 (may not find the protein thus also not any antibody)
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