AK1C2_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: AKR1C2 , DDH2
Protein names and data: AK1C2_HUMAN , Aldo-keto reductase family 1 member C2; 1.-.-.- , 3-alpha-HSD3; Chlordecone reductase homolog HAKRD; Dihydrodiol dehydrogenase 2; DD-2; DD2; Dihydrodiol dehydrogenase/bile acid-binding protein; DD/BABP; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; 1.3.1.20; Type III 3-alpha-hydroxysteroid dehydrogenase; 1.1.1.357 Lenght: 323 a.a.
Mass: 36735 Da
fasta formatted sequence
Function: Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.
Catalytic activity: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH. A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3- oxosteroid + NAD(P)H.
Disease:
Cellular location: Cytoplasm (Potential).
Tissue specificity: Expressed in fetal testes. Expressed in fetal and adult adrenal glands.

Genetic variants

Database cross-references

UniProt: P52895
Ensembl: ENST00000380753
Ensembl: ENST00000407674
Ensembl: ENST00000455190
Ensembl: ENST00000580545
MIM: 600450
MIM: 614279
neXtProt: NX_P52895
Antibodypedia: P52895 (may not find the protein thus also not any antibody)
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