AK1C3_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: AKR1C3 , DDH1, HSD17B5, KIAA0119, PGFS
Protein names and data: AK1C3_HUMAN , Aldo-keto reductase family 1 member C3; 1.-.-.- , 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; 1.1.1.357; Chlordecone reductase homolog HAKRb; Dihydrodiol dehydrogenase 3; DD-3; DD3; Dihydrodiol dehydrogenase type I; HA1753; Indanol dehydrogenase; 1.1.1.112; Prostaglandin F synthase; PGFS; 1.1.1.188; Testosterone 17-beta-dehydrogenase 5; 1.1.1.239; 1.1.1.64; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; 1.3.1.20 Lenght: 323 a.a.
Mass: 36853 Da
fasta formatted sequence
Function: Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Catalytic activity: Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH. A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3- oxosteroid + NAD(P)H. (5Z,13E)-(15S)-9-alpha,11-alpha,15- trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9- alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH. Testosterone + NAD(+) = androstenedione + NADH. Testosterone + NADP(+) = androst-4-ene-3,17- dione + NADPH. Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.
Cellular location: Cytoplasm.
Tissue specificity: Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.

Genetic variants

Database cross-references

UniProt: P42330
Ensembl: ENST00000380554
Ensembl: ENST00000583876
MIM: 603966
neXtProt: NX_P42330
Antibodypedia: P42330 (may not find the protein thus also not any antibody)
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