AKA7A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: AKAP7 , AKAP15, AKAP18
Protein names and data: AKA7A_HUMAN , A-kinase anchor protein 7 isoforms alpha and beta; AKAP-7 isoforms alpha and beta , A-kinase anchor protein 18 kDa; AKAP 18; Protein kinase A-anchoring protein 7 isoforms alpha/beta; PRKA7 isoforms alpha/beta Lenght: 104 a.a.
Mass: 11465 Da
fasta formatted sequence
Function: Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
Cellular location: Isoform Alpha: Lateral cell membrane; Lipid- anchor. Note=Targeted predominantly to the lateral membrane. Isoform Beta: Apical cell membrane; Lipid- anchor. Note=Targeted predominantly to the apical membrane.
Tissue specificity: Expressed in brain, heart, lung, pancreas and skeletal muscle.

Database cross-references

UniProt: O43687
Ensembl: ENST00000342266
Ensembl: ENST00000474850
MIM: 604693
neXtProt: NX_O43687
Antibodypedia: O43687 (may not find the protein thus also not any antibody)
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