AKT3_HUMAN

Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: AKT3 , PKBG
Protein names and data: AKT3_HUMAN , RAC-gamma serine/threonine-protein kinase; 2.7.11.1 , Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2 Lenght: 479 a.a.
Mass: 55775 Da
fasta formatted sequence

Function: AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Disease:
Cellular location: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
Tissue specificity: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.

Genetic variants

Database cross-references

UniProt: Q9Y243
Ensembl: ENST00000263826
Ensembl: ENST00000336199
Ensembl: ENST00000366539
Ensembl: ENST00000366540
MIM: 603387
MIM: 611223
neXtProt: NX_Q9Y243
Antibodypedia: Q9Y243 (may not find the protein thus also not any antibody)
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