AL9A1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ALDH9A1 , ALDH4, ALDH7, ALDH9
Protein names and data: AL9A1_HUMAN , 4-trimethylaminobutyraldehyde dehydrogenase; TMABADH; 1.2.1.47 , Aldehyde dehydrogenase E3 isozyme; Aldehyde dehydrogenase family 9 member A1; 1.2.1.3; Gamma-aminobutyraldehyde dehydrogenase; 1.2.1.19; R-aminobutyraldehyde dehydrogenase Lenght: 494 a.a.
Mass: 53802 Da
fasta formatted sequence
Function: Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.
Catalytic activity: 4-trimethylammoniobutanal + NAD(+) + H(2)O = 4-trimethylammoniobutanoate + NADH. An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH. 4-aminobutanal + NAD(+) + H(2)O = 4- aminobutanoate + NADH.
Pathway: Amine and polyamine biosynthesis; carnitine biosynthesis.
Cellular location: Cytoplasm (By similarity).
Tissue specificity: High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain. Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole.

Genetic variants

Database cross-references

UniProt: P49189
Ensembl: ENST00000354775
MIM: 602733
neXtProt: NX_P49189
Antibodypedia: P49189 (may not find the protein thus also not any antibody)
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