AMGO2_HUMAN

Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: AMIGO2 , ALI1
Protein names and data: AMGO2_HUMAN , Amphoterin-induced protein 2 , AMIGO-2; Alivin-1; Differentially expressed in gastric adenocarcinomas; DEGA; Flags: Precursor Lenght: 522 a.a.
Mass: 57934 Da
fasta formatted sequence
Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
Cellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Nucleus (By similarity). Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity).
Tissue specificity: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.

Database cross-references

UniProt: Q86SJ2
Ensembl: ENST00000266581
Ensembl: ENST00000321382
Ensembl: ENST00000429635
Ensembl: ENST00000550413
neXtProt: NX_Q86SJ2
Antibodypedia: Q86SJ2 (may not find the protein thus also not any antibody)
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