AN32A_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ANP32A , C15orf1, LANP, MAPM, PHAP1
Protein names and data: AN32A_HUMAN , Acidic leucine-rich nuclear phosphoprotein 32 family member A , Acidic nuclear phosphoprotein pp32; Leucine-rich acidic nuclear protein; LANP; Mapmodulin; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; Putative HLA-DR-associated protein I; PHAPI Lenght: 249 a.a.
Mass: 28585 Da
fasta formatted sequence
Function: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression.
Cellular location: Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm.
Tissue specificity: Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala.

Database cross-references

UniProt: P39687
Ensembl: ENST00000465139
MIM: 600832
neXtProt: NX_P39687
Antibodypedia: P39687 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.