ANLN_HUMAN

Source: hRBCD ; ID: IPI00032958
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ANLN
Protein names and data: ANLN_HUMAN , Actin-binding protein anillin Lenght: 1124 a.a.
Mass: 124199 Da
fasta formatted sequence
Function: Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression.
Cellular location: Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
Tissue specificity: Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.

Genetic variants

Database cross-references

UniProt: Q9NQW6
Ensembl: ENST00000265748
Ensembl: ENST00000396068
neXtProt: NX_Q9NQW6
Antibodypedia: Q9NQW6 (may not find the protein thus also not any antibody)
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