AP2A_HUMAN

Source: PM19886704
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TFAP2A , AP2TF, TFAP2
Protein names and data: AP2A_HUMAN , Transcription factor AP-2-alpha; AP2-alpha , AP-2 transcription factor; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2 Lenght: 437 a.a.
Mass: 48062 Da
fasta formatted sequence
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
Disease:
Cellular location: Nucleus.

Genetic variants

Database cross-references

UniProt: P05549
Ensembl: ENST00000319516
Ensembl: ENST00000379604
Ensembl: ENST00000379608
Ensembl: ENST00000482890
MIM: 107580
MIM: 113620
neXtProt: NX_P05549
Antibodypedia: P05549 (may not find the protein thus also not any antibody)
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