RBCC

APOA_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: LPA
Protein names and data: APOA_HUMAN , Apolipoprotein(a); Apo(a); Lp(a); 3.4.21.-; Flags: Precursor Lenght: 4548 a.a.
Mass: 501319 Da
fasta formatted sequence
Function: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.

Genetic variants

The reference genome sequence encodes a variant that contains 16 Kringle domains and that lack residues 533 to 3040. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 38 copies of the kringle-type repeats.

3498 - 3498 R -> Q (in dbSNP:rs41259144). VAR_047293 41259144
3866 - 3866 L -> V (in dbSNP:rs7765803). VAR_047294 7765803
3880 - 3880 L -> V (in dbSNP:rs7765781). VAR_047295 7765781
3907 - 3907 T -> P (in dbSNP:rs41272110). VAR_047296 41272110
3929 - 3929 R -> Q (in dbSNP:rs41272112). VAR_047297 41272112
4106 - 4106 M -> T (in dbSNP:rs41264308). VAR_047298 41264308
4187 - 4187 M -> T (in dbSNP:rs1801693). VAR_047299 1801693
4193 - 4193 W -> R (loss of lysine-sepharose binding). VAR_006633
4330 - 4330 G -> A (in dbSNP:rs41265936). VAR_047300 41265936
4399 - 4399 I -> M (in dbSNP:rs3798220). VAR_047301 3798220
4524 - 4524 R -> C (in dbSNP:rs3124784). VAR_047302 3124784

Database cross-references

UniProt: P08519
Ensembl: ENST00000316300
Ensembl: ENST00000447678
MIM: 152200
neXtProt: NX_P08519
Antibodypedia: P08519 (may not find the protein thus also not any antibody)
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RBCC Red Blood Cell Collection

APOA_HUMAN

Genetic variants

Database cross-references

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