RBCC Red Blood Cell Collection

APOC3_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: APOC3
Protein names and data: APOC3_HUMAN , Apolipoprotein C-III; Apo-CIII; ApoC-III , Apolipoprotein C3; Flags: Precursor Lenght: 99 a.a.
Mass: 10852 Da
fasta formatted sequence
Function: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
Disease: ( OMIM: 107720 614028 ) Hyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Note=The disease is caused by mutations affecting the gene represented in this entry.
Cellular location: Secreted.
Tissue specificity: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.

Genetic variants

78 - 78 K -> E (in HALP2). VAR_000643
94 - 94 T -> A (in C-III-0; unglycosylated). VAR_000644

Database cross-references

UniProt: P02656
Ensembl: ENST00000227667
MIM: 107720
MIM: 614028
neXtProt: NX_P02656
Antibodypedia: P02656 (may not find the protein thus also not any antibody)
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