RBCC Red Blood Cell Collection

APOH_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: APOH , B2G1
Protein names and data: APOH_HUMAN , Beta-2-glycoprotein 1 , APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I; B2GPI; Beta(2)GPI; Flags: Precursor Lenght: 345 a.a.
Mass: 38298 Da
fasta formatted sequence
Function: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
Cellular location: Secreted.
Tissue specificity: Expressed by the liver and secreted in plasma.

Genetic variants

5 - 5 V -> A (in dbSNP:rs3826358). VAR_048316 3826358
107 - 107 S -> N (in allele APOH*1; dbSNP:rs1801692). VAR_008169 1801692
154 - 154 R -> H (in dbSNP:rs8178847). VAR_019155 8178847
266 - 266 V -> L (in 23% of the population; dbSNP:rs4581). VAR_000673 4581
325 - 325 C -> G (loss of phosphatidylserine- binding; dbSNP:rs1801689). VAR_008170 1801689
335 - 335 W -> S (in allele APOH*3W; loss of phosphatidylserine-binding; dbSNP:rs1801690). VAR_008171 1801690

Database cross-references

UniProt: P02749
Ensembl: ENST00000205948
MIM: 138700
neXtProt: NX_P02749
Antibodypedia: P02749 (may not find the protein thus also not any antibody)
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