ARF1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ARF1
Protein names and data: ARF1_HUMAN , ADP-ribosylation factor 1 Lenght: 181 a.a.
Mass: 20697 Da
fasta formatted sequence
Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
Cellular location: Golgi apparatus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity).

Database cross-references

UniProt: P84077
Ensembl: ENST00000272102
Ensembl: ENST00000540651
Ensembl: ENST00000541182
MIM: 103180
neXtProt: NX_P84077
Antibodypedia: P84077 (may not find the protein thus also not any antibody)
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