Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: ARF6
Protein names and data: ARF6_HUMAN , ADP-ribosylation factor 6 Lenght: 175 a.a.
Mass: 20082 Da
fasta formatted sequence

Function: GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
Cellular location: Golgi apparatus. Cell membrane; Lipid- anchor. Endosome membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor (Probable). Cell projection, filopodium membrane; Lipid-anchor. Midbody (By similarity). Cytoplasm (By similarity). Cleavage furrow (By similarity). Note=Distributed throughout the cytoplasm during metaphase. Transiently detected at the ingressing cleavage furrow during mitotic cytokinesis. Recruited to the midbody at later stages of cytokinesis; this requires interaction with KIF23 (By similarity). Recruited to the cell membrane in association with CYTH2 and ARL4C. Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles.
Tissue specificity: Ubiquitous, with higher levels in heart, substantia nigra, and kidney.

Database cross-references

UniProt: P62330
Ensembl: ENST00000298316
MIM: 600464
neXtProt: NX_P62330
Antibodypedia: P62330 (may not find the protein thus also not any antibody)
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