ARFG1_HUMAN

Source: PM19886704
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ARFGAP1 , ARF1GAP
Protein names and data: ARFG1_HUMAN , ADP-ribosylation factor GTPase-activating protein 1; ARF GAP 1 , ADP-ribosylation factor 1 GTPase-activating protein; ARF1 GAP; ARF1-directed GTPase-activating protein Lenght: 406 a.a.
Mass: 44668 Da
fasta formatted sequence
Function: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).
Cellular location: Cytoplasm (By similarity). Golgi apparatus (By similarity). Note=Associates with the Golgi complex (By similarity).

Genetic variants

Database cross-references

UniProt: Q8N6T3
Ensembl: ENST00000353546
Ensembl: ENST00000370275
Ensembl: ENST00000370283
MIM: 608377
neXtProt: NX_Q8N6T3
Antibodypedia: Q8N6T3 (may not find the protein thus also not any antibody)
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