RBCC Red Blood Cell Collection

ARFG3_HUMAN

Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ARFGAP3 , ARFGAP1
Protein names and data: ARFG3_HUMAN , ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3 Lenght: 516 a.a.
Mass: 56928 Da
fasta formatted sequence
Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.
Cellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum- Golgi intermediate compartment.
Tissue specificity: Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary.

Genetic variants

231 - 231 S -> G (in dbSNP:rs9607957). VAR_055523 9607957
290 - 290 E -> G (in a breast cancer sample; somatic mutation). VAR_036177
355 - 355 S -> R (in dbSNP:rs1018448). VAR_013447 1018448
370 - 370 S -> G (in dbSNP:rs16986123). VAR_055524 16986123
468 - 468 Q -> H (in dbSNP:rs35498349). VAR_055525 35498349
482 - 482 A -> T (in dbSNP:rs36003980). VAR_055526 36003980
490 - 490 Q -> R (in dbSNP:rs11551619). VAR_055527 11551619

Database cross-references

UniProt: Q9NP61
Ensembl: ENST00000263245
Ensembl: ENST00000437119
MIM: 612439
neXtProt: NX_Q9NP61
Antibodypedia: Q9NP61 (may not find the protein thus also not any antibody)
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