ARHL2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ADPRHL2 , ARH3
Protein names and data: ARHL2_HUMAN , Poly(ADP-ribose) glycohydrolase ARH3; 3.2.1.143 , ADP-ribosylhydrolase 3; [Protein ADP-ribosylarginine] hydrolase-like protein 2; Flags: Precursor Lenght: 363 a.a.
Mass: 38947 Da
fasta formatted sequence
Function: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria.
Catalytic activity: Hydrolyzes poly(ADP-D-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-D- ribose.
Cellular location: Cytoplasm. Mitochondrion matrix. Nucleus.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q9NX46
Ensembl: ENST00000373178
MIM: 610624
neXtProt: NX_Q9NX46
Antibodypedia: Q9NX46 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.