ARI1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ARIH1 , ARI, MOP6, UBCH7BP , HUSSY-27
Protein names and data: ARI1_HUMAN , E3 ubiquitin-protein ligase ARIH1; 6.3.2.- , H7-AP2; HHARI; Monocyte protein 6; MOP-6; Protein ariadne-1 homolog; ARI-1; UbcH7-binding protein; UbcM4-interacting protein; Ubiquitin-conjugating enzyme E2-binding protein 1 Lenght: 557 a.a.
Mass: 64118 Da
fasta formatted sequence
Function: E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Cytoplasm. Note=Mainly cytoplasmic.
Tissue specificity: Widely expressed.

Database cross-references

UniProt: Q9Y4X5
Ensembl: ENST00000379887
MIM: 605624
neXtProt: NX_Q9Y4X5
Antibodypedia: Q9Y4X5 (may not find the protein thus also not any antibody)
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