ARK72_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: AKR7A2 , AFAR, AFAR1, AKR7
Protein names and data: ARK72_HUMAN , Aflatoxin B1 aldehyde reductase member 2; 1.1.1.n11 , AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase Lenght: 359 a.a.
Mass: 39589 Da
fasta formatted sequence
Function: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Catalytic activity: 4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH.
Cellular location: Golgi apparatus (By similarity). Cytoplasm.
Tissue specificity: Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.

Genetic variants

Database cross-references

UniProt: O43488
Ensembl: ENST00000235835
MIM: 603418
neXtProt: NX_O43488
Antibodypedia: O43488 (may not find the protein thus also not any antibody)
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