Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: ASAP1 , DDEF1, KIAA1249
Protein names and data: ASAP1_HUMAN , Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 , 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; Development and differentiation-enhancing factor 1; DEF-1; Differentiation-enhancing factor 1; PIP2-dependent ARF1 GAP Lenght: 1129 a.a.
Mass: 125498 Da
fasta formatted sequence

Function: Possesses phosphatidylinositol 4,5-bisphosphate- dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.
Cellular location: Cytoplasm (By similarity). Membrane (By similarity). Note=Predominantly cytoplasmic (By similarity). Partially membrane-associated (By similarity).

Genetic variants

Database cross-references

UniProt: Q9ULH1
Ensembl: ENST00000357668
Ensembl: ENST00000518721
MIM: 605953
neXtProt: NX_Q9ULH1
Antibodypedia: Q9ULH1 (may not find the protein thus also not any antibody)
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