ASNA_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ASNA1 , ARSA, TRC40
Protein names and data: ASNA_HUMAN , ATPase ASNA1; 3.6.-.- , Arsenical pump-driving ATPase; Arsenite-stimulated ATPase; Transmembrane domain recognition complex 40 kDa ATPase subunit; hARSA-I; hASNA-I Lenght: 348 a.a.
Mass: 38793 Da
fasta formatted sequence
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.
Cellular location: Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.
Tissue specificity: Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle.

Genetic variants

Database cross-references

UniProt: O43681
Ensembl: ENST00000357332
Ensembl: ENST00000591090
MIM: 601913
neXtProt: NX_O43681
Antibodypedia: O43681 (may not find the protein thus also not any antibody)
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