Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: ATP2A3
Protein names and data: AT2A3_HUMAN , Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; SERCA3; SR Ca(2+)-ATPase 3; , Calcium pump 3 Lenght: 1043 a.a.
Mass: 113977 Da
fasta formatted sequence

Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Catalytic activity: ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
Cellular location: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue specificity: Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines.

Genetic variants

Database cross-references

UniProt: Q93084
Ensembl: ENST00000309890
Ensembl: ENST00000352011
Ensembl: ENST00000359983
Ensembl: ENST00000397035
Ensembl: ENST00000397041
Ensembl: ENST00000397043
Ensembl: ENST00000570845
Ensembl: ENST00000572116
MIM: 601929
neXtProt: NX_Q93084
Antibodypedia: Q93084 (may not find the protein thus also not any antibody)
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