AT8A1_HUMAN

Source: hRBCD ; ID: IPI00032402
PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ATP8A1 , ATPIA
Protein names and data: AT8A1_HUMAN , Probable phospholipid-transporting ATPase IA; 3.6.3.1 , ATPase class I type 8A member 1; Chromaffin granule ATPase II Lenght: 1164 a.a.
Mass: 131369 Da
fasta formatted sequence
Function: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles.
Catalytic activity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
Cellular location: Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Multi-pass membrane protein (By similarity). Cytoplasmic granule. Cell membrane. Endoplasmic reticulum. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures.
Tissue specificity: Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle.

Genetic variants

Database cross-references

UniProt: Q9Y2Q0
Ensembl: ENST00000264449
Ensembl: ENST00000381668
MIM: 609542
neXtProt: NX_Q9Y2Q0
Antibodypedia: Q9Y2Q0 (may not find the protein thus also not any antibody)
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