ATG3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ATG3 , APG3, APG3L
Protein names and data: ATG3_HUMAN , Ubiquitin-like-conjugating enzyme ATG3; 6.3.2.- , Autophagy-related protein 3; APG3-like; hApg3; Protein PC3-96 Lenght: 314 a.a.
Mass: 35864 Da
fasta formatted sequence
Function: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Cellular location: Cytoplasm.
Tissue specificity: Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.

Database cross-references

UniProt: Q9NT62
Ensembl: ENST00000283290
Ensembl: ENST00000402314
MIM: 609606
neXtProt: NX_Q9NT62
Antibodypedia: Q9NT62 (may not find the protein thus also not any antibody)
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