ATG4A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ATG4A , APG4A, AUTL2
Protein names and data: ATG4A_HUMAN , Cysteine protease ATG4A; 3.4.22.- , AUT-like 2 cysteine endopeptidase; Autophagin-2; Autophagy-related cysteine endopeptidase 2; Autophagy-related protein 4 homolog A; hAPG4A Lenght: 398 a.a.
Mass: 45378 Da
fasta formatted sequence
Function: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Cellular location: Cytoplasm (By similarity).
Tissue specificity: Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.

Database cross-references

UniProt: Q8WYN0
Ensembl: ENST00000345734
Ensembl: ENST00000372232
Ensembl: ENST00000372254
MIM: 300663
neXtProt: NX_Q8WYN0
Antibodypedia: Q8WYN0 (may not find the protein thus also not any antibody)
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