ATG4B_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ATG4B , APG4B, AUTL1, KIAA0943
Protein names and data: ATG4B_HUMAN , Cysteine protease ATG4B; 3.4.22.- , AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B Lenght: 393 a.a.
Mass: 44294 Da
fasta formatted sequence
Function: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Cellular location: Cytoplasm (By similarity).
Tissue specificity: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.

Genetic variants

Database cross-references

UniProt: Q9Y4P1
Ensembl: ENST00000402096
Ensembl: ENST00000404914
Ensembl: ENST00000405546
MIM: 611338
neXtProt: NX_Q9Y4P1
Antibodypedia: Q9Y4P1 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.