ATG7_HUMAN
Source: PM19886704PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ATG7 , APG7L
Protein names and data: ATG7_HUMAN , Ubiquitin-like modifier-activating enzyme ATG7 , ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; Ubiquitin-activating enzyme E1-like protein Lenght: 703 a.a.
Mass: 77960 Da
fasta formatted sequence
Function: E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
Cellular location: Cytoplasm (By similarity). Preautophagosomal structure (By similarity). Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity).
Tissue specificity: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
Genetic variants
Database cross-references
UniProt: O95352Ensembl: ENST00000354449
Ensembl: ENST00000354956
Ensembl: ENST00000446450
MIM: 608760
neXtProt: NX_O95352
Antibodypedia: O95352 (may not find the protein thus also not any antibody)
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