ATG9A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ATG9A , APG9L1
Protein names and data: ATG9A_HUMAN , Autophagy-related protein 9A , APG9-like 1; mATG9 Lenght: 839 a.a.
Mass: 94447 Da
fasta formatted sequence
Function: Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.
Cellular location: Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation- induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.

Genetic variants

Database cross-references

UniProt: Q7Z3C6
Ensembl: ENST00000361242
Ensembl: ENST00000396761
Ensembl: ENST00000409033
Ensembl: ENST00000409422
Ensembl: ENST00000409618
MIM: 612204
neXtProt: NX_Q7Z3C6
Antibodypedia: Q7Z3C6 (may not find the protein thus also not any antibody)
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