ATPA_HUMAN

Source: PM23856902
BSc_CH
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: ATP5A1 , ATP5A, ATP5AL2, ATPM
Protein names and data: ATPA_HUMAN , ATP synthase subunit alpha, mitochondrial; Flags: Precursor Lenght: 553 a.a.
Mass: 59751 Da
fasta formatted sequence
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
Disease:
Cellular location: Mitochondrion inner membrane. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Colocalizes with HRG on the cell surface of T-cells.
Tissue specificity: Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord.

Genetic variants

Database cross-references

UniProt: P25705
Ensembl: ENST00000282050
Ensembl: ENST00000398752
Ensembl: ENST00000593152
MIM: 164360
MIM: 615228
neXtProt: NX_P25705
Antibodypedia: P25705 (may not find the protein thus also not any antibody)
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